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KMID : 1059519910350030253
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Journal of the Korean Chemical Society
1991 Volume.35 No. 3 p.253 ~ p.257
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Synthetic Studies on Phospholipid Derivatives 1. Comparative Syntheses of (R)-and (S)-Glycerol Acetonide
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Chung Sung-Ki
Kim B.-E
Chang K.-S.
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Abstract
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The optically active glycerol acetonides are often used as important chiral intermediates for many syntheses. In connection with the development of inhibitors of phospholipases, we have compared the synthetic routes to (S)-and (R)-glycerol acetonide from D-mannitol and D-isoascorbic acid, and L-serine and L-ascorbic acid, respectively. In our hands, the conversions of L-serine to (R)-glycerol acetonide and of D-mannitol to (S)-glycerol acetonide were found to be most effective.
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